Ontology highlight
ABSTRACT:
SUBMITTER: Kjos I
PROVIDER: S-EPMC5623852 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
EMBO reports 20170823 10
Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. The autophagic pathway maintains basal cellular homeostasis and helps cells adapt during stress; thus, defects in autophagy can cause detrimental effects. It is therefore crucial that autophagy is properly regulated. In this study, we show that the cysteine protease Atg4B, a key ...[more]