Ontology highlight
ABSTRACT:
SUBMITTER: Hartlehnert M
PROVIDER: S-EPMC5624882 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Hartlehnert Maike M Derksen Angelika A Hagenacker Tim T Kindermann David D Schäfers Maria M Pawlak Mathias M Kieseier Bernd C BC Meyer Zu Horste Gerd G
Scientific reports 20171002 1
The activation of T helper cells requires antigens to be exposed on the surface of antigen presenting cells (APCs) via MHC class II (MHC-II) molecules. Expression of MHC-II is generally limited to professional APCs, but other cell types can express MHC-II under inflammatory conditions. However, the importance of these conditional APCs is unknown. We and others have previously shown that Schwann cells are potentially conditional APCs, but the functional relevance of MHC-II expression by Schwann c ...[more]