Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC5628867 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Wu Qunfeng Q Pi Liya L Le Trinh Thu T Zuo Chaohui C Xia Man M Jiao Yu Y Hou Zhouhua Z Jo Sung S Puszyk William W Pham Kien K Nelson David R DR Robertson Keith K Ostrov David D Rameshwar Pranela P Xia Chang Qing CQ Liu Chen C
Molecular therapy : the journal of the American Society of Gene Therapy 20170810 10
Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate worldwide, with limited treatment options. Glypican-3 (GPC3) is a glycosylphosphatidylinositol-anchored glycoprotein that is overexpressed in most HCC tissues but not in normal tissues. GPC3-targeting antibody therapy shows limited response in a clinical trial due to the lack of a tumor-specific cytotoxic T lymphocyte (CTL) response. Here, in C57/B6 mice, we demonstrated that intravenous infusion of GPC3-coupled lymphocytes ( ...[more]