Ontology highlight
ABSTRACT:
SUBMITTER: Leonardi M
PROVIDER: S-EPMC5629381 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20170915
The pseudo-five-component reaction between β-dicarbonyl compounds (2 molecules), diamines and α-iodoketones (2 molecules), prepared in situ from aryl ketones, was performed efficiently under mechanochemical conditions involving high-speed vibration milling with a single zirconium oxide ball. This reaction afforded symmetrical frameworks containing two pyrrole or fused pyrrole units joined by a spacer, which are of interest in the exploration of chemical space for drug discovery purposes. The met ...[more]