Ontology highlight
ABSTRACT:
SUBMITTER: Howard JL
PROVIDER: S-EPMC5629391 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20170914
Solventless mechanochemical synthesis represents a technique with improved sustainability metrics compared to solvent-based processes. Herein, we describe a methodical process to run one solventless reaction directly into another through multistep mechanochemistry, effectively amplifying the solvent savings. The approach has to consider the solid form of the materials and compatibility of any auxiliary used. This has culminated in the development of a two-step, one-jar protocol for heterocycle f ...[more]