Ontology highlight
ABSTRACT:
SUBMITTER: Boshkow J
PROVIDER: S-EPMC5632803 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Boshkow J J Fischer S S Bailey A M AM Wolfrum S S Carreira E M EM
Chemical science 20170809 10
The syntheses of (+)-16-<i>epi</i>- and (+)-11,15-di-<i>epi</i>-danicalipin A (<b>2</b> and <b>3</b>) are reported. The conformations of the parent diols <b>5</b> and <b>6</b> as well as the corresponding disulfates <b>2</b> and <b>3</b> were determined on the basis of <i>J</i>-based configuration analysis and supported by calculations. The impact of configuration on membrane permeability in Gram-negative bacteria and mammalian cell lines was assessed as well as cytotoxicity. Although diastereom ...[more]