Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging.
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ABSTRACT:
SUBMITTER: Anders DA
PROVIDER: S-EPMC5633808 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
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Electrochemical [<sup>11</sup>C]CO<sub>2</sub> to [<sup>11</sup>C]CO conversion for PET imaging.
Anders David A DA Bongarzone Salvatore S Fortt Robin R Gee Antony D AD Long Nicholas J NJ
Chemical communications (Cambridge, England) 20170301 20
The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([<sup>11</sup>C]CO) from cyclotron-produced carbon-11 carbon dioxide ([<sup>11</sup>C]CO<sub>2</sub>) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [<sup>11</sup>C]CO from [<sup>11</sup>C]CO<sub>2</sub>. Produced [<sup>11</sup>C]CO was subsequently converted to [<sup>11</sup>C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) ...[more]
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