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Increased weight gain by C-section: Functional significance of the primordial microbiome.

ABSTRACT: Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development.

SUBMITTER: Martinez KA 

PROVIDER: S-EPMC5636202 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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Increased weight gain by C-section: Functional significance of the primordial microbiome.

Martinez Keith A KA   Devlin Joseph C JC   Lacher Corey R CR   Yin Yue Y   Cai Yi Y   Wang Jincheng J   Dominguez-Bello Maria G MG  

Science advances 20171011 10

Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relati  ...[more]