Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC5636883 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Zhao Cheng C Shen Xiaofang X Wu Rui R Li Ling L Pan Zishu Z
Scientific reports 20171011 1
The classical swine fever virus (CSFV) nonstructural protein p7 is crucial for virus production, yet precisely how the p7 modulates this process is unclear. In this study, we first identified the interactions of p7 with E2 and NS2. The key binding regions of both p7 and NS2 mapped to the first transmembrane (TM1) domain of two proteins. Three amino acid substitutions in the TM1 region of p7 (p7<sup>TDI18/19/20AAA</sup>, p7<sup>EVV21/22/23AAA</sup> and p7<sup>YFY25/26/30AAA</sup>) impaired infect ...[more]