Ontology highlight
ABSTRACT:
SUBMITTER: Queval CJ
PROVIDER: S-EPMC5637157 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Queval Christophe J CJ Song Ok-Ryul OR Carralot Jean-Philippe JP Saliou Jean-Michel JM Bongiovanni Antonino A Deloison Gaspard G Deboosère Nathalie N Jouny Samuel S Iantomasi Raffaella R Delorme Vincent V Debrie Anne-Sophie AS Park Sei-Jin SJ Gouveia Joana Costa JC Tomavo Stanislas S Brosch Roland R Yoshimura Akihiko A Yeramian Edouard E Brodin Priscille P
Cell reports 20170901 13
Pathogens have evolved a range of mechanisms to counteract host defenses, notably to survive harsh acidic conditions in phagosomes. In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achieved by interfering with the retention of the V-ATPase complexes at the vacuole. Here, we present evidence that M. tuberculosis resorts to yet another strategy to control phagosomal acidification, interfering with host suppressor of cytokine signaling ...[more]