Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt O
PROVIDER: S-EPMC5637908 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Schmidt Oliver O Weyer Yannick Y Fink Matthias J MJ Müller Martin M Weys Sabine S Bindreither Marietta M Teis David D
FEBS letters 20170824 18
Rab5 GTPases are master regulators of early endosome biogenesis and transport. The genome of Saccharomyces cerevisiae encodes three Rab5 proteins: Vps21, the major isoform, Ypt52 and Ypt53. Here, we show that Vps21 is the most abundant Rab5 protein and Ypt53 is the least abundant. In stressed cells, Ypt53 levels increase but never exceed that of Vps21. Its induction requires the transcription factors Crz1 and Gis1. In growing cells, the expression of Ypt53 is suppressed by post-transcriptional m ...[more]