Monitoring cerebral hemodynamic change during transcranial ultrasound stimulation using optical intrinsic signal imaging.

ABSTRACT: Transcranial ultrasound stimulation (tUS) is a promising non-invasive approach to modulate brain circuits. The application is gaining popularity, however the full effect of ultrasound stimulation is still unclear and further investigation is needed. This study aims to apply optical intrinsic signal imaging (OISI) for the first time, to simultaneously monitor the wide-field cerebral hemodynamic change during tUS on awake animal with high spatial and temporal resolution. Three stimulation paradigms were delivered using a single-element focused transducer operating at 425?kHz in pulsed mode having the same intensity (ISPPA?=?1.84?W/cm2, ISPTA?=?129?mW/cm2) but varying pulse repetition frequencies (PRF). The results indicate a concurrent hemodynamic change occurring with all actual tUS but not under a sham stimulation. The stimulation initiated the increase of oxygenated hemoglobin (HbO) and decrease of deoxygenated hemoglobin (RHb). A statistically significant difference (p?

SUBMITTER: Kim E 

PROVIDER: S-EPMC5640689 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other