Ontology highlight
ABSTRACT:
SUBMITTER: Gilley J
PROVIDER: S-EPMC5640801 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Cell reports 20171001 1
Studies with the Wld<sup>S</sup> mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration). Crucially, an absence of SARM1 delays Wallerian degeneration as robustly as Wld<sup>S</sup>, but their relative capacities to confer long-term protection against related, non-injury axonopathy and/or synaptopathy have not been directly compared. While Sarm1 deletion or Wld ...[more]