Epigenome-wide association study of asthma and wheeze in childhood and adolescence.
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ABSTRACT:
SUBMITTER: Arathimos R
PROVIDER: S-EPMC5640901 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Publications
Epigenome-wide association study of asthma and wheeze in childhood and adolescence.
Arathimos Ryan R Suderman Matthew M Sharp Gemma C GC Burrows Kimberley K Granell Raquel R Tilling Kate K Gaunt Tom R TR Henderson John J Ring Susan S Richmond Rebecca C RC Relton Caroline L CL
Clinical epigenetics 20171013
<h4>Background</h4>Asthma heritability has only been partially explained by genetic variants and is known to be sensitive to environmental factors, implicating epigenetic modifications such as DNA methylation in its pathogenesis.<h4>Methods</h4>Using data collected in the Avon Longitudinal Study of Parents and Children (ALSPAC), we assessed associations of asthma and wheeze with DNA methylation at 7.5 and 16.5 years, at over 450,000 CpG sites in DNA from the peripheral blood of approx. 1000 part ...[more]
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