Ontology highlight
ABSTRACT:
SUBMITTER: Morgenstern Y
PROVIDER: S-EPMC5641904 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Morgenstern Yael Y Das Adhikari Upasana U Ayyash Muneef M Elyada Ela E Tóth Beáta B Moor Andreas A Itzkovitz Shalev S Ben-Neriah Yinon Y
The EMBO journal 20170928 20
The intestinal epithelium holds an immense regenerative capacity mobilized by intestinal stem cells (ISCs), much of it supported by Wnt pathway activation. Several unique regulatory mechanisms ensuring optimal levels of Wnt signaling have been recognized in ISCs. Here, we identify another Wnt signaling amplifier, CKIε, which is specifically upregulated in ISCs and is essential for ISC maintenance, especially in the absence of its close isoform CKIδ. Co-ablation of CKIδ/ε in the mouse gut epithel ...[more]