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Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.


ABSTRACT: Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome mediated by pathogenic CD4+ T and B cells, but the function of extrafollicular and germinal center CD4+ T and B interactions in cGVHD pathogenesis remains largely unknown. Here we show that extrafollicular CD4+ T and B interactions are sufficient for inducing cGVHD, while germinal center formation is dispensable. The pathogenesis of cGVHD is associated with the expansion of extrafollicular CD44hiCD62loPSGL-1loCD4+ (PSGL-1loCD4+) T cells. These cells express high levels of ICOS, and the blockade of ICOS/ICOSL interaction prevents their expansion and ameliorates cGVHD. Expansion of PSGL-1loCD4+ T cells is also prevented by BCL6 or Stat3 deficiency in donor CD4+ T cells, with the induction of cGVHD ameliorated by BCL6 deficiency and completely suppressed by Stat3 deficiency in donor CD4+ T cells. These results support that Stat3- and BCL6-dependent extrafollicular CD4+ T and B interactions play critical functions in the pathogenesis of cGVHD.Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.

SUBMITTER: Deng R 

PROVIDER: S-EPMC5645449 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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Extrafollicular CD4<sup>+</sup> T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Deng Ruishu R   Hurtz Christian C   Song Qingxiao Q   Yue Chanyu C   Xiao Gang G   Yu Hua H   Wu Xiwei X   Muschen Markus M   Forman Stephen S   Martin Paul J PJ   Zeng Defu D  

Nature communications 20171017 1


Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome mediated by pathogenic CD4<sup>+</sup> T and B cells, but the function of extrafollicular and germinal center CD4<sup>+</sup> T and B interactions in cGVHD pathogenesis remains largely unknown. Here we show that extrafollicular CD4<sup>+</sup> T and B interactions are sufficient for inducing cGVHD, while germinal center formation is dispensable. The pathogenesis of cGVHD is associated with the expansion of extrafollicular C  ...[more]