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Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy.

ABSTRACT: Increases in ?-synuclein protein expression are suspected to increase the risk of the development of Parkinson's disease (PD). A recent study has demonstrated that ?2-adrenergic receptor (?2AR) agonists decrease histone acetylation in the ?-synuclein gene and suppress transcription. Coupled with the anti-inflammatory effects that are associated with ?2AR activation, this two-pronged attack holds promise for PD treatment and the development of new therapeutic approaches for this disease.

SUBMITTER: Abdelmotilib H

PROVIDER: S-EPMC5649055 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy.

Abdelmotilib Hisham H West Andrew B AB

Genome medicine 20171019 1

Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson's disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription. Coupled with the anti-inflammatory effects that are associated with β2AR activation, this two-pronged attack holds promise for PD treatment and the development of new therapeutic approaches for this disease. ...[more]

PMID: 29052536

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