Ontology highlight
ABSTRACT:
SUBMITTER: Steeland S
PROVIDER: S-EPMC5651799 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Steeland Sophie S Van Ryckeghem Sara S Van Imschoot Griet G De Rycke Riet R Toussaint Wendy W Vanhoutte Leen L Vanhove Christian C De Vos Filip F Vandenbroucke Roosmarijn E RE Libert Claude C
Scientific reports 20171020 1
TNF has as detrimental role in multiple sclerosis (MS), however, anti-TNF medication is not working. Selective TNF/TNFR1 inhibition whilst sparing TNFR2 signaling reduces the pro-inflammatory effects of TNF but preserves the important neuroprotective signals via TNFR2. We previously reported the generation of a Nanobody-based selective inhibitor of human TNFR1, TROS that will be tested in experimental autoimmune encephalomyelitis (EAE). We specifically antagonized TNF/TNFR1 signaling using TROS ...[more]