Ontology highlight
ABSTRACT:
SUBMITTER: Shin KC
PROVIDER: S-EPMC5651811 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Shin Kyung Cheul KC Hwang Injae I Choe Sung Sik SS Park Jeu J Ji Yul Y Kim Jong In JI Lee Gha Young GY Choi Sung Hee SH Ching Jianhong J Kovalik Jean-Paul JP Kim Jae Bum JB
Nature communications 20171020 1
Obesity is closely associated with increased adipose tissue macrophages (ATMs), which contribute to systemic insulin resistance and altered lipid metabolism by creating a pro-inflammatory environment. Very low-density lipoprotein receptor (VLDLR) is involved in lipoprotein uptake and storage. However, whether lipid uptake via VLDLR in macrophages affects obesity-induced inflammatory responses and insulin resistance is not well understood. Here we show that elevated VLDLR expression in ATMs promo ...[more]