Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.
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ABSTRACT:
SUBMITTER: Chikahisa S
PROVIDER: S-EPMC5651881 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
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Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.
Chikahisa Sachiko S Harada Saki S Shimizu Noriyuki N Shiuchi Tetsuya T Otsuka Airi A Nishino Seiji S Séi Hiroyoshi H
Scientific reports 20171020 1
We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function a ...[more]
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