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TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function.

ABSTRACT: Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND participants to examine associations of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469 participants, 322 subjects died. TMAO was positively associated with age, body mass index, type 2 diabetes mellitus and inversely with estimated glomerular filtration rate (eGFRcreatcysC)(all P?

SUBMITTER: Gruppen EG 

PROVIDER: S-EPMC5653802 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function.

Gruppen Eke G EG   Garcia Erwin E   Connelly Margery A MA   Jeyarajah Elias J EJ   Otvos James D JD   Bakker Stephan J L SJL   Dullaart Robin P F RPF  

Scientific reports 20171023 1

Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND participants to examine associations of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469 participants, 322 subjects died. TMAO was positively associated w  ...[more]