Ontology highlight
ABSTRACT:
SUBMITTER: Pandey M
PROVIDER: S-EPMC5653875 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Pandey Manisha M Powell Jessica J Calcutt Ainslie A Zaman Mehfuz M Phillips Zachary N ZN Ho Mei Fong MF Batzloff Michael R MR Good Michael F MF
Scientific reports 20171023 1
Globally, group A streptococcal infections are responsible for over 500,000 deaths per year. A safe vaccine that does not induce autoimmune pathology and that affords coverage for most GAS serotypes is highly desired. We have previously demonstrated that a vaccine based on the conserved M-protein epitope, J8 was safe and immunogenic in a pilot Phase I study. We subsequently improved vaccine efficacy by incorporation of a B-cell epitope from the IL-8 protease, SpyCEP, which protected IL-8 and enh ...[more]