Ontology highlight
ABSTRACT:
SUBMITTER: Merilahti JAM
PROVIDER: S-EPMC5662267 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Merilahti Johannes A M JAM Ojala Veera K VK Knittle Anna M AM Pulliainen Arto T AT Elenius Klaus K
Molecular biology of the cell 20170913 22
Receptor tyrosine kinases (RTKs) have been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a soluble intracellular receptor fragment with functional activity. For most RTKs, however, it is unknown whether they can exploit this new signaling mechanism. Here we used a system-wide screen to address the frequency of susceptibility to gamma-secretase cleavage among human RTKs. The ...[more]