Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.
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ABSTRACT:
SUBMITTER: Giddings O
PROVIDER: S-EPMC5664212 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.
Giddings Olivia O Esther Charles R CR
Pediatric pulmonology 20170717 S48
Cystic fibrosis is characterized by an overly exuberant neutrophilic inflammatory response to pathogens and other stimuli that starts very early in disease. The overwhelming nature of this response is a primary cause of remodeling and destruction of the airways, suggesting that anti-inflammatory therapies could be beneficial in CF. However, finding therapies that can effectively reduce the inflammatory response without compromising host defenses remains elusive. New approaches towards mapping in ...[more]
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