Ontology highlight
ABSTRACT:
SUBMITTER: Zolea F
PROVIDER: S-EPMC5666848 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Zolea Fabiana F Battaglia Anna Martina AM Chiarella Emanuela E Malanga Donatella D De Marco Carmela C Bond Heather Mandy HM Morrone Giovanni G Costanzo Francesco F Biamonte Flavia F
International journal of molecular sciences 20171017 10
Erythroid differentiation is a complex and multistep process during which an adequate supply of iron for hemoglobinization is required. The role of ferritin heavy subunit, in this process, has been mainly attributed to its capacity to maintain iron in a non-toxic form. We propose a new role for ferritin heavy subunit (FHC) in controlling the erythroid commitment of K562 erythro-myeloid cells. FHC knockdown induces a change in the balance of GATA transcription factors and significantly reduces th ...[more]