Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC5668883 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Tang J J Zhan M-N MN Yin Q-Q QQ Zhou C-X CX Wang C-L CL Wo L-L LL He M M Chen G-Q GQ Zhao Q Q
Oncogenesis 20171009 10
Aberrant activation of nuclear factor-κB (NF-κB) has been observed in a wide range of human cancers and is thought to promote tumorigenesis and metastasis. As a central component of NF-κB pathway, p65 protein level is tightly regulated and could be subjected to proteasome degradation. Here we demonstrated that p65 can bind to HSC70 with four consensus recognition motif in its RHD domain and be constitutively transported to the lysosome membrane to bind with lysosome-associated membrane protein t ...[more]