Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5669891 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Wang Song S Wang Xiao X Li Jiangfeng J Meng Shuai S Liang Zhen Z Xu Xin X Zhu Yi Y Li Shiqi S Wu Jian J Xu Mingjie M Ji Alin A Lin Yiwei Y Liu Ben B Zheng Xiangyi X Xie Bo B Xie Liping L
Oncotarget 20170719 47
miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of miR-493-5p expression pattern and its function in prostate cancer remains to be elucidated. Here, we illustrate that miR-493-5p is frequently downregulated in prostate cancer, at least partially due to altered DNA methylation. miR-493-5p functions as a tumor suppressor in prostate cancer cells. c-Met, CREB1 and EGFR are downstream target genes of miR-493-5p. miR-493-5p inhibits EMT ...[more]