Ontology highlight
ABSTRACT:
SUBMITTER: Ahn M
PROVIDER: S-EPMC5670245 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Ahn Minkoo M Waudby Christopher A CA Bernardo-Gancedo Ana A De Genst Erwin E Dhulesia Anne A Salvatella Xavier X Christodoulou John J Dobson Christopher M CM Kumita Janet R JR
Scientific reports 20171103 1
Populating transient and partially unfolded species is a crucial step in the formation and accumulation of amyloid fibrils formed from pathogenic variants of human lysozyme linked with a rare but fatal hereditary systemic amyloidosis. The partially unfolded species possess an unstructured β-domain and C-helix with the rest of the α-domain remaining native-like. Here we use paramagnetic relaxation enhancement (PRE) measured by NMR spectroscopy to study the transient intermolecular interactions be ...[more]