Ontology highlight
ABSTRACT:
SUBMITTER: Zilberman Y
PROVIDER: S-EPMC5674880 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Zilberman Yuliya Y Abrams Joshua J Anderson Dorian C DC Nance Jeremy J
The Journal of cell biology 20170913 11
During morphogenesis, adherens junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion. Here, we examine the function of Rho guanosine triphosphatase CDC-42 in AJ formation and regulation during <i>Caenorhabditis elegans</i> embryo elongation, a process driven by asymmetric epidermal cell shape changes. <i>cdc-42</i> mutant embryos arrest during elongation with epidermal ruptures. Unexpectedly, we find using time-lapse fluorescence imaging that <i>cdc-42</i> ...[more]