Ontology highlight
ABSTRACT:
SUBMITTER: Kvainickas A
PROVIDER: S-EPMC5674888 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Kvainickas Arunas A Jimenez-Orgaz Ana A Nägele Heike H Hu Zehan Z Dengjel Jörn J Steinberg Florian F
The Journal of cell biology 20170921 11
The retromer complex, which recycles the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to the trans-Golgi network (TGN), is thought to consist of a cargo-selective VPS26-VPS29-VPS35 trimer and a membrane-deforming subunit of sorting nexin (SNX)-Bin, Amphyphysin, and Rvs (BAR; SNX-BAR) proteins. In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI- ...[more]