Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.
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ABSTRACT:
SUBMITTER: Erdogan B
PROVIDER: S-EPMC5674895 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.
Erdogan Begum B Ao Mingfang M White Lauren M LM Means Anna L AL Brewer Bryson M BM Yang Lijie L Washington M Kay MK Shi Chanjuan C Franco Omar E OE Weaver Alissa M AM Hayward Simon W SW Li Deyu D Webb Donna J DJ
The Journal of cell biology 20171011 11
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood. In this study, we show that fibronectin (Fn) assembled by CAFs mediates CAF-cancer cell association and directional migration. Compared with normal fibroblasts, CAFs produce an Fn-rich extracellular matrix with anisotropic fiber orientation, which guides the cancer cells to migrate d ...[more]
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