Ontology highlight
ABSTRACT:
SUBMITTER: Schreiber R
PROVIDER: S-EPMC5683855 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Schreiber Renate R Diwoky Clemens C Schoiswohl Gabriele G Feiler Ursula U Wongsiriroj Nuttaporn N Abdellatif Mahmoud M Kolb Dagmar D Hoeks Joris J Kershaw Erin E EE Sedej Simon S Schrauwen Patrick P Haemmerle Guenter G Zechner Rudolf R
Cell metabolism 20171005 5
Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose triglyceride lipase (ATGL) is considered a key step in NST. Accordingly, the severe cold intolerance of global ATGL knockout (AKO) mice has been attributed to defective BAT lipolysis. Here we show that this conclusion is incorrect. We demonstrate that although the BAT-specific loss of ATGL impairs BAT lipolysis and alters BAT m ...[more]