Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari F
PROVIDER: S-EPMC5684865 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Ferrari Federica F Malfacini Davide D Journigan Blair V BV Bird Mark F MF Trapella Claudio C Guerrini Remo R Lambert David G DG Calo' Girolamo G Zaveri Nurulain T NT
Pharmacology research & perspectives 20170801 4
Nociceptin/orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP), a member of the opioid receptor family. We recently identified a new high affinity and highly selective NOP agonist AT-403. In this study, we characterized the functional profile of AT-403 and compared it to other known nonpeptide NOP agonists Ro 65-6570, Ro 2q, SCH-221510, MCOPPB, AT-202 and SCH-486757, using the following assays: GTPγ[<sup>35</sup> S] stimulated binding, ...[more]