Ontology highlight
ABSTRACT:
SUBMITTER: Benvegnu S
PROVIDER: S-EPMC5685682 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Benvegnù Stefano S Wahle Tina T Dotti Carlos G CG
Oncotarget 20170810 52
Altered processing of the Amyloid Precursor Protein (APP) is a well-recognized central pathogenic mechanism in Alzheimer's Disease (AD), and regulation of APP processing is a major focus of research in the AD field. However, how age-associated cellular and molecular changes contribute to changes in the amyloidogenic processing of APP have not been extensively clarified so far. We here provide evidence that the processing of APP is influenced by the e3 ubiquitin ligase Mahogunin (MGRN1), a neurop ...[more]