Ontology highlight
ABSTRACT:
SUBMITTER: Vivian CJ
PROVIDER: S-EPMC5690839 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Vivian Carolyn J CJ Brinker Amanda E AE Graw Stefan S Koestler Devin C DC Legendre Christophe C Gooden Gerald C GC Salhia Bodour B Welch Danny R DR
Cancer research 20170629 22
Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s)-designated Mitochondrial Nuclear Exchange (MNX)-we showed that mtDNA could alter mammary tumor metastasis. Because retrograde and anterograde communication exists between the nuclear and mitochondrial genomes, we hypothesized that there are differenti ...[more]