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Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment.


ABSTRACT: Intracellular insulin may exhibit a long-term effect in regulating protein synthesis, DNA synthesis, and gene transcription. However, the intracellular delivery of insulin is a great challenge. Here, we describe how a simple biomineralization modification of insulin can transport it into intact cells on a large scale, leading to a long-term therapeutic effect on diabetes mellitus. Using insulin-resistant HepG2 cell and diabetic KKAy mice as models, in vitro and in vivo assessments have demonstrated that biomineralized insulin nanoparticles can trigger glucose metabolism, and this improvement extends after the treatment. The potential exists to improve the current treatment of type 2 diabetes mellitus through biomineralized modifications of insulin. This study provides a new paradigm of biomimetic nanotechnology for biomedical applications.

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC5695014 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment.

Xiao Yun Y   Wang Xiaoyu X   Wang Ben B   Liu Xueyao X   Xu Xurong X   Tang Ruikang R  

Theranostics 20170926 17


Intracellular insulin may exhibit a long-term effect in regulating protein synthesis, DNA synthesis, and gene transcription. However, the intracellular delivery of insulin is a great challenge. Here, we describe how a simple biomineralization modification of insulin can transport it into intact cells on a large scale, leading to a long-term therapeutic effect on diabetes mellitus. Using insulin-resistant HepG2 cell and diabetic KKAy mice as models, <i>in vitro</i> and <i>in vivo</i> assessments  ...[more]

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