Ontology highlight
ABSTRACT:
SUBMITTER: Dai J
PROVIDER: S-EPMC5698275 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Frontiers in immunology 20171117
Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs after pro-inflammatory sepsis transitions to the later chronic anti-inflammatory and immunosuppressive phenotype. The purpose of this study was to determine whether intracellular S100A9 protein might sustain Gr1<sup>+< ...[more]