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Cell-Free DNA in Oncology: Gearing up for Clinic.

ABSTRACT: In the past several years, interest in the clinical utility of cell-free DNA as a noninvasive cancer biomarker has grown rapidly. Success in the development of plasma genotyping assays and other liquid biopsy assays has widened the scope of cell-free DNA use in research and the clinic. Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a wide array of clinical settings and modalities. These include plasma genotyping as a tool for early diagnosis, the detection of minimal residual disease, and the evaluation of treatment response/progression. In this review, we assess the clinical landscape of plasma genotyping assays and propose strategies for their further expansion into routine clinical care.

SUBMITTER: Ulrich BC

PROVIDER: S-EPMC5700141 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Cell-Free DNA in Oncology: Gearing up for Clinic.

Ulrich Bryan C BC Paweletz Cloud P CP

Annals of laboratory medicine 20180101 1

In the past several years, interest in the clinical utility of cell-free DNA as a noninvasive cancer biomarker has grown rapidly. Success in the development of plasma genotyping assays and other liquid biopsy assays has widened the scope of cell-free DNA use in research and the clinic. Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a ...[more]

PMID: 29071812

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