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Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential.

ABSTRACT: Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.

SUBMITTER: Agrawal S

PROVIDER: S-EPMC5702503 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential.

Agrawal Shivankar S Acharya Debabrata D Adholeya Alok A Barrow Colin J CJ Deshmukh Sunil K SK

Frontiers in pharmacology 20171121

Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonri ...[more]

PMID: 29209209

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