Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.
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ABSTRACT:
SUBMITTER: Maldonado EM
PROVIDER: S-EPMC5702902 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics.
Maldonado Elaina M EM Leoncikas Vytautas V Fisher Ciarán P CP Moore J Bernadette JB Plant Nick J NJ Kierzek Andrzej M AM
CPT: pharmacometrics & systems pharmacology 20170908 11
The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonst ...[more]
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