Ontology highlight
ABSTRACT:
SUBMITTER: Simmons AB
PROVIDER: S-EPMC5703318 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20171107 47
Mature mammalian neurons have a limited ability to extend neurites and make new synaptic connections, but the mechanisms that inhibit such plasticity remain poorly understood. Here, we report that OFF-type retinal bipolar cells in mice are an exception to this rule, as they form new anatomical connections within their tiled dendritic fields well after retinal maturity. The Down syndrome cell-adhesion molecule (<i>Dscam</i>) confines these anatomical rearrangements within the normal tiled fields, ...[more]