Ontology highlight
ABSTRACT:
SUBMITTER: Murray J
PROVIDER: S-EPMC5703543 | biostudies-other | 2017
REPOSITORIES: biostudies-other
PloS one 20171127 11
Using genome-wide small interfering RNA (siRNA) screens for poliovirus, influenza A virus and rotavirus, we validated the top 6 gene hits PV, RV or IAV to search for host genes that when knocked-down (KD) enhanced virus permissiveness and replication over wild type Vero cells or HEp-2 cells. The enhanced virus replication was tested for 12 viruses and ranged from 2-fold to >1000-fold. There were variations in virus-specific replication (strain differences) across the cell lines examined. Some ho ...[more]