Ontology highlight
ABSTRACT:
SUBMITTER: Schettini F
PROVIDER: S-EPMC5704698 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Schettini Francesco F Buono Giuseppe G Trivedi Meghana V MV De Placido Sabino S Arpino Grazia G Giuliano Mario M
Breast care (Basel, Switzerland) 20171019 5
Estrogen receptor (ER) signaling represents the main driver of tumor growth and survival in luminal breast cancer (BC). Despite the efficacy of endocrine agents, many patients with luminal BC do not respond to endocrine therapy and many others develop endocrine resistance over time, due to the activation of escape pathways such as the PI3K/AKT/mTOR signaling. Several clinical trials have demonstrated the efficacy of mTOR and PI3K inhibitors in overcoming endocrine resistance in hormone receptor- ...[more]