Ontology highlight
ABSTRACT:
SUBMITTER: Tamahara T
PROVIDER: S-EPMC5705818 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Tamahara Toru T Ochiai Kyoko K Muto Akihiko A Kato Yukinari Y Sax Nicolas N Matsumoto Mitsuyo M Koseki Takeyoshi T Igarashi Kazuhiko K
Molecular and cellular biology 20171128 24
The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps, including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular mechanisms of Bach2 regulation in response to signaling of cytokines and antigen. We show here that mammalian target of rapamycin (mTOR) controls Bach2 along B cell differentiation with two distinct mechanisms in pre-B cells. First, mTOR complex 1 (m ...[more]