Ontology highlight
ABSTRACT:
SUBMITTER: Malesci A
PROVIDER: S-EPMC5706531 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Malesci Alberto A Bianchi Paolo P Celesti Giuseppe G Basso Gianluca G Marchesi Federica F Grizzi Fabio F Di Caro Giuseppe G Cavalleri Tommaso T Rimassa Lorenza L Palmqvist Richard R Lugli Alessandro A Koelzer Viktor H VH Roncalli Massimo M Mantovani Alberto A Ogino Shuji S Laghi Luigi L
Oncoimmunology 20170712 12
Tumor-associated macrophages (TAMs) play a role in tumor development and progression. We hypothesized that abundance of TAMs might modify efficacy of 5-fluorouracil chemotherapy in colorectal cancer. We measured the density of CD68+ TAMs at the invasive front of primary tumor of colorectal carcinoma (PT-TAMs; n = 208), at available matched metastatic lymph node (LN-TAMs; n = 149), and in an independent set of primary colorectal cancers (PT-TAMs, n = 111). The hazard ratios for disease-free survi ...[more]