Ontology highlight
ABSTRACT:
SUBMITTER: Melis MHM
PROVIDER: S-EPMC5706841 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Melis Monique H M MHM Nevedomskaya Ekaterina E van Burgsteden Johan J Cioni Bianca B van Zeeburg Hester J T HJT Song Ji-Ying JY Zevenhoven John J Hawinkels Lukas J A C LJAC de Visser Karin E KE Bergman Andries M AM
Oncotarget 20170928 55
Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers, including prostate cancer. Reports on the contribution of the adaptive immune system are contradictive, since both suppression and acceleration of disease development have been reported. This study addresses the functional role of lymphocytes in prostate cancer development using a genetically engineered mouse model (GEMM) of human c-Myc dri ...[more]