LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression.
Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC5706886 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
LDB2 inhibits proliferation and migration in liver cancer cells by abrogating <i>HEY1</i> expression.
Yu Hongyang H Jia Ruichun R Zhao Ling L Song Shigang S Gu Jing J Zhang Haogang H
Oncotarget 20171010 55
Hepatocellular carcinoma (HCC) was one of the most common cancers around the world, has very low 5-year survival rate. However, the mechanism of HCC occurrence and development is largely unknown. LDB2 belongs to the LIM-domain binding family and functions as an adaptor for transcriptional regulation. Here we found that LDB2 is downregulated in HCC samples. LDB2 has the ability to inhibit proliferation and migration of hepatocarcinoma cells. We found that the proliferation and migration abilities ...[more]
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