Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies.

ABSTRACT: Designing synthetic polymer assemblies that can sense a biological signal to mimic cell activities is elusive. We develop a class of block copolymer containing bioinspired host units as supramolecular catchers for the highly-selective capture of adenosine-5'-triphosphate (ATP). Driven by ATP, these block copolymers undergo a stepwise self-assembly and exhibit cascading deformation into highly-ordered nanostructures via the specific recognition effect between ATP and the receptor. By modulating the ATP concentration, one can precisely control the biomimetic evolution of these assemblies in diverse dimensionalities and geometries, like certain organellar deformations. Moreover, the ATP/polymer hybrid aggregates can be reversibly disassembled in response to phosphatase. The special ability of the artificial assemblies to sense intracellular bioactivators can offer new insight into bio-responsive nanomaterials for cellular applications.

SUBMITTER: Yan Q

PROVIDER: S-EPMC5707515 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Publications

ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies.

Yan Qiang Q Zhao Yue Y

Chemical science 20150507 7

Designing synthetic polymer assemblies that can sense a biological signal to mimic cell activities is elusive. We develop a class of block copolymer containing bioinspired host units as supramolecular catchers for the highly-selective capture of adenosine-5'-triphosphate (ATP). Driven by ATP, these block copolymers undergo a stepwise self-assembly and exhibit cascading deformation into highly-ordered nanostructures <i>via</i> the specific recognition effect between ATP and the receptor. By modul ...[more]

PMID: 29218205

Similar Datasets

Temporal and Triggered Evolution of Host-Guest Characteristics in Amphiphilic Polymer Assemblies.

Project description:An amphiphilic polymer with cleavable side chain and main chain functional groups has been designed and synthesized. Specific cleavage of either of its functional groups was found to have an effect on the morphology of the assembly. Degradation of the main chain is shown to cause morphology of the supramolecular assembly to evolve with time from a micelle-like assembly to a vesicular assembly. On the other hand, stimulus-induced cleavage of the side chains causes these nanoassemblies to disassemble. These temporal (main chain) and triggered (side chain) degradation processes have implications in the design of degradable polymers as supramolecular scaffolds for biological applications.

| S-EPMC4917414 | biostudies-literature

Communicating assemblies of biomimetic nanocapsules.

Project description:Communication assemblies between biomimetic nanocapsules in a 3D closed system with self-regulating and self-organization functionalities were demonstrated for the first time. Two types of biomimetic nanocapsules, TiO2/polydopamine capsules and SiO2/polyelectrolytes capsules with different stimuli-responsive properties were prepared and leveraged to sense the external stimulus, transmit chemical signaling, and autonomic communication-controlled release of active cargos. The capsules have clear core-shell structures with average diameters of 30 nm and 25 nm, respectively. The nitrogen adsorption-desorption isotherms and thermogravimetric analysis displayed their massive pore structures and encapsulation capacity of 32% of glycine pH buffer and 68% of benzotriazole, respectively. Different from the direct release mode of the single capsule, the communication assemblies show an autonomic three-stage release process with a "jet lag" feature, showing the internal modulation ability of self-controlled release efficiency. The control overweight ratios of capsules influences on communication-release interaction between capsules. The highest communication-release efficiency (89.6% of benzotriazole) was achieved when the weight ratio of TiO2/polydopamine/SiO2/polyelectrolytes capsules was 5 : 1 or 10 : 1. Communication assemblies containing various types of nanocapsules can autonomically perform complex tasks in a biomimetic fashion, such as cascaded amplification and multidirectional communication platforms in bioreactors.

| S-EPMC8265773 | biostudies-literature

Bioinspired supramolecular nanosheets of zinc chlorophyll assemblies.

Project description:Two-dimensional sheet-like supramolecules have attracted much attention from the viewpoints of their potential application as functional (nano)materials due to unique physical and chemical properties. One of the supramolecular sheet-like nanostructures in nature is visible in the self-assemblies of bacteriochlorophyll-c-f pigments inside chlorosomes, which are major components in the antenna systems of photosynthetic green bacteria. Herein, we report artificial chlorosomal supramolecular nanosheets prepared by the self-assembly of a synthetic zinc 31-methoxy-chlorophyll derivative having amide and urea groups in the substituent at the 17-position. The semi-synthetic zinc chlorophyll derivative kinetically formed dimeric species and transformed into more thermodynamically stable chlorosomal J-aggregates in the solid state. The kinetically and thermodynamically formed self-assemblies had particle-like and sheet-like supramolecular nanostructures, respectively. The resulting nanosheets of biomimetic chlorosomal J-aggregates had flat surfaces and well-ordered supramolecular structures. The artificial sheet-like nanomaterial mimicking chlorosomal bacteriochlorophyll-c-f J-aggregates was first constructed by the model molecule, and is potentially useful for various applications including artificial light-harvesting antennas and photosyntheses.

| S-EPMC6773735 | biostudies-literature

Bioinspired Stable and Photoluminescent Assemblies for Power Generation.

Project description:Peptide assemblies are ideal components for eco-friendly optoelectronic energy harvesting devices due to their intrinsic biocompatibility, ease of fabrication, and flexible functionalization. However, to date, their practical applications have been limited due to the difficulty in obtaining stable, high-performance devices. Here, it is shown that the tryptophan-based simplest peptide cyclo-glycine-tryptophan (cyclo-GW) forms mechanically robust (elastic modulus up to 24.0 GPa) and thermally stable up to 370 °C monoclinic crystals, due to a supramolecular packing combining dense parallel ?-sheet hydrogen bonding and herringbone edge-to-face aromatic interactions. The directional and extensive driving forces further confer unique optical properties, including aggregation-induced blue emission and unusual stable photoluminescence. Moreover, the crystals produce a high and sustained open-circuit voltage (1.2 V) due to a high piezoelectric coefficient of 14.1 pC N-1 . These findings demonstrate the feasibility of utilizing self-assembling peptides for fabrication of biointegrated microdevices that combine high structural stability, tailored optoelectronics, and significant energy harvesting properties.

| S-EPMC6430416 | biostudies-literature

Synthesis and characterization of phenylboronic acid-containing polymer for glucose-triggered drug delivery.

Project description:Thermo-, pH- and glucose-responsive polymeric nanoparticles are of great interest in developing a self-regulated drug delivery system. The novel core-shell nanoparticles were synthesized by self-assembly of a phenylboronic acid-based block copolymer poly-(N-isopropylacrylamide)-block-poly(3-acrylamidophenylboronic acid) (PNIPAM136-b-PAPBA16) and a fluorescent complex glucosamine-poly(N-isopropylacrylamide)/Eu(III) (GA-PNIPAM)/Eu(III) based on the cross-linking between PBA- and GA-containing blocks in this work. The nanoparticles can be tuned via thermo-induced collapse or glucose-induced swelling at appropriate pH and temperatures; they had an average kinetic radius was about 80nm, and which showed excellent fluorescence. MTT assays revealed the nanocarriers had no signiﬁcant cytotoxic response of the micelle when it was observed in the cell line over the concentration range from 0.1 to 1000 μg/ml at any exposure times.

| S-EPMC6968588 | biostudies-literature

Bioinspired Microstructured Polymer Surfaces with Antireflective Properties.

Project description:Over the years, different approaches to obtaining antireflective surfaces have been explored, such as using index-matching, interference, or micro- and nanostructures. Structural super black colors are ubiquitous in nature, and biomimicry thus constitutes an interesting way to develop antireflective surfaces. Moth-eye nanostructures, for example, are well known and have been successfully replicated using micro- and nanofabrication. However, other animal species, such as birds of paradise and peacock spiders, have evolved to display larger structures with antireflective features. In peacock spiders, the antireflective properties of their super black patches arise from relatively simple microstructures with lens-like shapes organized in tightly packed hexagonal arrays, which makes them a good candidate for cheap mass replication techniques. In this paper, we present the fabrication and characterization of antireflective microarrays inspired by the peacock spider's super black structures encountered in nature. Firstly, different microarrays 3D models are generated from a surface equation. Secondly, the arrays are fabricated in a polyacrylate resin by super-resolution 3D printing using two-photon polymerization. Thirdly, the resulting structures are inspected using a scanning electron microscope. Finally, the reflectance and transmittance of the printed structures are characterized at normal incidence with a dedicated optical setup. The bioinspired microlens arrays display excellent antireflective properties, with a measured reflectance as low as 0.042 ± 0.004% for normal incidence, a wavelength of 550 nm, and a collection angle of 14.5°. These values were obtained using a tightly-packed array of slightly pyramidal lenses with a radius of 5 µm and a height of 10 µm.

| S-EPMC8470586 | biostudies-literature

Bioinspired and Biomimetic Nanotherapies for the Treatment of Infectious Diseases.

Project description:There are still great challenges for the effective treatment of infectious diseases, although considerable achievement has been made by using antiviral and antimicrobial agents varying from small-molecule drugs, peptides/proteins, to nucleic acids. The nanomedicine approach is emerging as a new strategy capable of overcoming disadvantages of molecular therapeutics and amplifying their anti-infective activities, by localized delivery to infection sites, reducing off-target effects, and/or attenuating resistance development. Nanotechnology, in combination with bioinspired and biomimetic approaches, affords additional functions to nanoparticles derived from synthetic materials. Herein, we aim to provide a state-of-the-art review on recent progress in biomimetic and bioengineered nanotherapies for the treatment of infectious disease. Different biomimetic nanoparticles, derived from viruses, bacteria, and mammalian cells, are first described, with respect to their construction and biophysicochemical properties. Then, the applications of diverse biomimetic nanoparticles in anti-infective therapy are introduced, either by their intrinsic activity or by loading and site-specifically delivering various molecular drugs. Bioinspired and biomimetic nanovaccines for prevention and/or therapy of infectious diseases are also highlighted. At the end, major translation issues and future directions of this field are discussed.

| S-EPMC6624236 | biostudies-literature

A bioinspired hydrogen bond-triggered ultrasensitive ionic mechanoreceptor skin.

Project description:Biological cellular structures have inspired many scientific disciplines to design synthetic structures that can mimic their functions. Here, we closely emulate biological cellular structures in a rationally designed synthetic multicellular hybrid ion pump, composed of hydrogen-bonded [EMIM+][TFSI-] ion pairs on the surface of silica microstructures (artificial mechanoreceptor cells) embedded into thermoplastic polyurethane elastomeric matrix (artificial extracellular matrix), to fabricate ionic mechanoreceptor skins. Ionic mechanoreceptors engage in hydrogen bond-triggered reversible pumping of ions under external stimulus. Our ionic mechanoreceptor skin is ultrasensitive (48.1-5.77 kPa-1) over a wide spectrum of pressures (0-135 kPa) at an ultra-low voltage (1?mV) and demonstrates the ability to surpass pressure-sensing capabilities of various natural skin mechanoreceptors (i.e., Merkel cells, Meissner's corpuscles, Pacinian corpuscles). We demonstrate a wearable drone microcontroller by integrating our ionic skin sensor array and flexible printed circuit board, which can control directions and speed simultaneously and selectively in aerial drone flight.

| S-EPMC6728325 | biostudies-literature

A Synthetic Bioinspired Carbohydrate Polymer with Mucoadhesive Properties.

Project description:Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical definition and solubility, while the chemical synthesis of polysaccharides is challenging with few reported examples of synthetic carbohydrate polymers with engineered-in ionic functionality. We report the design, synthesis, and evaluation of a synthetic, cationic, enantiopure carbohydrate polymer inspired by the structure of chitosan. These water-soluble, cytocompatible polymers are prepared via an anionic ring-opening polymerization of a bicyclic β-lactam sugar monomer. The synthetic method provides control over the site of amine functionalization and the length of the polymer while providing narrow dispersities. These well-defined polymers are mucoadhesive as documented in single-molecule scale (AFM), bulk solution phase (FRAP), and ex vivo tissue experiments. Polymer length and functionality affects bioactivity as long, charged polymers display higher mucoadhesivity than long, neutral polymers or short, charged polymers.

| S-EPMC7754715 | biostudies-literature

Biomimetic Reversible Heat-Stiffening Polymer Nanocomposites.

Project description:Inspired by the ability of the sea cucumber to (reversibly) increase the stiffness of its dermis upon exposure to a stimulus, we herein report a stimuli-responsive nanocomposite that can reversibly increase its stiffness upon exposure to warm water. Nanocomposites composed of cellulose nanocrystals (CNCs) that are grafted with a lower critical solution temperature (LCST) polymer embedded within a poly(vinyl acetate) (PVAc) matrix show a dramatic increase in modulus, for example, from 1 to 350 MPa upon exposure to warm water, the hypothesis being that grafting the polymers from the CNCs disrupts the interactions between the nanofibers and minimizes the mechanical reinforcement of the film. However, exposure to water above the LCST leads to the collapse of the polymer chains and subsequent stiffening of the nanocomposite as a result of the enhanced CNC interactions. Backing up this hypothesis are energy conserving dissipative particle dynamics (EDPD) simulations which show that the attractive interactions between CNCs are switched on upon the temperature-induced collapse of the grafted polymer chains, resulting in the formation of a percolating reinforcing network.

| S-EPMC5571458 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data