Ontology highlight
ABSTRACT:
SUBMITTER: Ellens KW
PROVIDER: S-EPMC5714238 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Ellens Kenneth W KW Christian Nils N Singh Charandeep C Satagopam Venkata P VP May Patrick P Linster Carole L CL
Nucleic acids research 20171101 20
The post-genomic era has provided researchers with a deluge of protein sequences. However, a significant fraction of the proteins encoded by sequenced genomes remains without an identified function. Here, we aim at determining how many enzymes of uncertain or unknown function are still present in the Saccharomyces cerevisiae and human proteomes. Using information available in the Swiss-Prot, BRENDA and KEGG databases in combination with a Hidden Markov Model-based method, we estimate that >600 y ...[more]