Ontology highlight
ABSTRACT:
SUBMITTER: Donnelly SK
PROVIDER: S-EPMC5716284 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Donnelly Sara K SK Cabrera Ramon R Mao Serena P H SPH Christin John R JR Wu Bin B Guo Wenjun W Bravo-Cordero Jose Javier JJ Condeelis John S JS Segall Jeffrey E JE Hodgson Louis L
The Journal of cell biology 20171023 12
The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue. Invadopodia are actin-based protrusions that mediate the matrix degradation necessary for invasion and metastasis of tumor cells. We demonstrate that Rac3 GTPase is critical for integrating the adhesion of invadopodia to the extracellular matrix (ECM) with their ability to degrade the ECM in breast tumor cells. We identify two pathways at invadopodia important for integrin activation and delivery of ...[more]